digoxin in chronic heart failure with reduced ejection fraction in people with chronic kidney disease (CKD) Amiodarone (Cordarone) is a complex antiarrhythmic agent with multiple electrophysiologic effects, unusual pharmacokinetics, and numerous potentially harmful drug interactions and adverse effects. Severe hyperkalaemia. This patient presented to ED with pulmonary oedema after missing several dialysis sessions. Shortly after this ECG was taken, the HR dropped to 10 bpm with no palpable pulse requiring a brief period of CPR. Digoxin, sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. Digoxin is taken by mouth or by injection into a vein. Digitalis toxicity can be caused by high levels of digitalis in the body. A lower tolerance to the drug can also cause digitalis toxicity. People with lower tolerance may have a normal level of digitalis in their blood. Mechanism. The ECG features of digoxin effect are seen with therapeutic doses of digoxin and are due to: Shortening of the atrial and ventricular refractory periods — producing a short QT interval with secondary repolarisation abnormalities affecting the ST segments, T waves and U waves. Various ECG changes are associated with the use of digoxin: ST depression and T wave inversion in V5-6 in a reversed tick pattern. Changes are more extensive in digoxin toxicity. Digoxin toxicity, also known as digoxin poisoning, is a type of poisoning that occurs in people who take too much of the medication digoxin or eat plants such as foxglove that contain a similar substance. For ventricular rate control in patients with chronic atrial fibrillation and/or atrial flutter†; or for the treatment of narrow-complex paroxysmal supraventricular tachycardia (PSVT)† or for paroxysmal supraventricular tachycardia (PSVT) prophylaxis† in patients without a delta wave on ECG during sinus rhythm; or for the treatment of. Digoxin Injection official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.